Fear generalization immediately after contextual fear memory consolidation in mice

Fear generalization is a symptom of anxiety-related disorders, including acute stress disorder and post-traumatic disorder. Using contextual fear conditioning paradigm, we found that mice exposed to similar neutral context but not different soon after training showed immediately memory consolidation (i.e., 6 h training). This was reflected by change only in the total amount also pattern freezing between conditioned generalized contexts. These results provide insight into factors influence can facilitate future studies investigating underlying pathophysiological mechanisms disorders.